Persistent IVF failure

Although 24 chromosome aneuploidy screening may ultimately benefit a broad range of IVF cycles there are some cycles which are particularly challenging and where 24sure might be considered. In particular; where maternal age is high, where three or more previous IVF cycles have not been successful, and where no contraindications or other confounding factors have been identified - there is increased evidence that aneuploidy may play a role.

Until recently visual inspection using FISH has been used to screen for aneuploidy in these more challenging cycles however research into the benefits of PGS FISH has failed to reach a positive consensus. This is believed to be due to a combination of the difficulty of producing and reading metaphase spreads reliably, variability in biopsy technique and the fact that FISH is only able to screen a limited subset of chromosomes.

As further studies, such as that being undertaken by the ESHRE PGS Task Force, are awaited there is growing belief that array based 24 chromosome screening should be considered a means of responding to persistent IVF failure.